Description

5'-o-Acetyl-2',3'-Dideoxy-2',3'-Didehydro-5-Fluoro-Uridine is a chemically modified nucleoside analog, a key intermediate in the synthesis of advanced antiviral and anticancer pharmaceuticals. This high-purity compound is critical for research and development in medicinal chemistry, enabling the creation of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic candidates with modified sugar moieties.
• Antiviral Drug Development: Serves as a precursor for potential drugs targeting viral polymerases, including those for HIV and hepatitis.
• Oncology Research: Investigated as an intermediate for prodrugs designed to inhibit cancer cell proliferation.
• Biochemical Tool Compound: Employed in enzymatic studies to understand the substrate specificity of nucleoside/nucleotide processing enzymes.
• Fine Chemical Synthesis: Used in custom synthesis and contract manufacturing of specialized, high-value chemical entities.

Basic Information

Product Name	5'-o-Acetyl-2',3'-Dideoxy-2',3'-Didehydro-5-Fluoro-Uridine
CAS No.	160203-74-7
Molecular Formula	C11H11FN2O5
Molecular Weight	270.22 g/mol
Synonyms	5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine; 2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine 5'-acetate; 5-Fluoro-5'-O-acetyl-2',3'-didehydro-2',3'-dideoxyuridine; 5-Fluoro-ddUrd 5'-acetate; 5-Fluoro-2',3'-didehydro-2',3'-dideoxyuridine 5'-acetate; FddUrd 5'-Acetate; 5-Fluoro-D4U 5'-Acetate; 160203-74-7
EINECS	Contact for details

Quality Control

Our 5'-o-Acetyl-2',3'-Dideoxy-2',3'-Didehydro-5-Fluoro-Uridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.