Description

L-744 832 is a highly selective, potent, and orally bioavailable neurokinin-1 (NK1) receptor antagonist developed for research and pharmaceutical applications. It is valued for its exceptional binding affinity and functional antagonism, enabling precise modulation of substance P signaling pathways in preclinical neuroscience and oncology studies. Researchers and pharmaceutical development teams rely on L-744 832 CAS NO 160141-09-3 for target validation, mechanism-of-action studies, and as a reference standard in assay development and PK/PD modeling.

Application

• Preclinical research on emesis (chemotherapy-induced nausea and vomiting) mechanisms and NK1 receptor pharmacology
• Neuroscience studies investigating central nervous system disorders including depression, anxiety, and pain modulation
• Pharmaceutical reference standard for HPLC and LC-MS method development and assay calibration
• Lead compound optimization and structure–activity relationship (SAR) studies in NK1-targeted drug discovery
• In vitro functional assays (e.g., calcium flux, cAMP inhibition) using human or primate NK1 receptors
• Bridging studies supporting regulatory submissions for next-generation NK1 antagonists
• Quality control testing of commercial NK1 receptor ligands and generic formulations

Basic Information

Product Name	L-744 832
CAS No.	160141-09-3
Molecular Formula	C25H25F3N4O2
Molecular Weight	478.49 g/mol
Synonyms	L-744832; L 744832; L744832; (2R,3R)-2-(1H-Indol-3-ylmethyl)-3-(2-methoxyphenyl)-N-(3-thienylcarbonyl)morpholine; (2R,3R)-2-[(1H-Indol-3-yl)methyl]-3-(2-methoxyphenyl)-N-(thiophene-3-carbonyl)morpholine; MK-869 analog; CP-99994 analog; Neurokinin-1 receptor antagonist L-744832
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of L-744 832 are tested for identity, purity, residual solvents, heavy metals, and microbiological contamination per ICH Q5, Q6, and Q7 guidelines. Testing includes HPLC, NMR, IR, and mass spectrometry to confirm structural integrity and batch-to-batch consistency. Compliant with ISO 9001:2015 and REACH regulations.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.0%
Related Substances (HPLC)	Each impurity ≤ 0.3%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Water (Karl Fischer)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.