Description

n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Cytidine Phosphoramidite is a highly specialized, protected nucleoside phosphoramidite building block used in the automated solid-phase synthesis of oligonucleotides. This compound is critical for the production of modified RNA sequences, where it enables the site-specific introduction of the cytidine analog with orthogonal protecting groups for precise deprotection control. It is an essential raw material for research and development in therapeutic oligonucleotide discovery, antisense technology, and diagnostic probe manufacturing.

Application

• Oligonucleotide Synthesis: Primary building block for the automated solid-phase synthesis of RNA and modified oligonucleotides.
• Therapeutic RNA Development: Key reagent in the production of siRNA, miRNA, and antisense oligonucleotides for pharmaceutical applications.
• Research Probes: Used to synthesize labeled or modified nucleic acid probes for genomic research, diagnostics, and hybridization studies.
• Antisense Drug Manufacturing: Critical component in the scalable synthesis of candidate drugs targeting specific mRNA sequences.
• Structural Biology Studies: Enables the incorporation of modified cytidine into oligonucleotides for NMR and crystallography studies.
• Diagnostic Kit Production: Used in the manufacture of high-specificity primers and probes for PCR and other molecular diagnostic assays.

Basic Information

Product Name	n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Cytidine Phosphoramidite
CAS No.	160107-23-3
Molecular Formula	C46H55FN3O9P
Molecular Weight	867.93 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(R)-1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl]-N4-benzoyl-2'-deoxycytidine 3'-[(2-Cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-FPMP-Ced-CE Phosphoramidite; 2'-O-(1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl)-5'-O-DMT-N4-Bz-2'-deoxycytidine-3'-CE Phosphoramidite; Ced Phosphoramidite, 2'-O-FPMP protected; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]-2'-deoxycytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
EINECS	Contact for details

Quality Control

Our n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Cytidine Phosphoramidite is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to meet the exacting standards of pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This material is hygroscopic and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.