Description

N2-iso-Butyroyl-3'-o-Methylguanosine is a chemically modified nucleoside derivative, specifically a guanosine analog with protective groups at the N2 and 3'-O positions. This compound is a critical building block in oligonucleotide synthesis and pharmaceutical research, enabling the study of RNA structure, function, and therapeutic applications. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, antisense drug development, and biochemical research where precise molecular modifications are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified oligonucleotides and nucleotide-based therapeutics.
• Antisense & RNAi Research: Used in the development and study of antisense oligonucleotides, siRNA, and other RNA-targeting agents.
• Biochemical Probe Synthesis: Essential for creating labeled or modified nucleosides to study RNA metabolism, structure, and protein interactions.
• Medicinal Chemistry: Serves as a precursor in the discovery and optimization of novel antiviral and anticancer nucleoside analogs.
• Academic & Industrial R&D: Employed in research laboratories for fundamental studies in molecular biology and nucleic acid chemistry.

Basic Information

Product Name	N2-iso-Butyroyl-3'-o-Methylguanosine
CAS No.	160107-07-3
Molecular Formula	C16H23N5O6
Molecular Weight	381.39 g/mol
Synonyms	3'-O-Methyl-N2-isobutyrylguanosine; Guanosine, N2-(2-methyl-1-oxopropyl)-3'-O-methyl-; 3'-O-Methyl-N2-isobutyryl-guanosine; N2-Isobutyryl-3'-O-methylguanosine; N2-(2-Methylpropanoyl)-3'-O-methylguanosine; 3'-OMe-N2-iBu-Guanosine; N2-iBu-3'-OMe-G
EINECS	Contact for details

Quality Control

Our N2-iso-Butyroyl-3'-o-Methylguanosine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.