Description

Lobradimil is a synthetic bradykinin B2 receptor agonist, a compound of significant interest in pharmaceutical research and development. Its primary value lies in its ability to selectively and transiently increase the permeability of the blood-brain barrier, enabling targeted delivery of therapeutic agents to the central nervous system. This makes it a critical research tool for neuroscientists and pharmaceutical companies focused on developing treatments for brain tumors, neurological disorders, and other CNS conditions. Lobradimil CAS NO 159768-75-9 represents a specialized, high-purity compound for advanced preclinical and clinical-stage investigations.

Application

• Blood-Brain Barrier (BBB) Modulation Research: Primary application as a pharmacological agent to temporarily and reversibly open the BBB for enhanced drug delivery.
• Oncology R&D: Investigational use in conjunction with chemotherapeutic agents to improve their efficacy against primary brain tumors and brain metastases.
• Neurological Disorder Studies: Research into novel treatment paradigms for Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions by facilitating CNS access for large-molecule biologics.
• Preclinical Model Development: Utilized in animal models to study BBB physiology, pharmacokinetics, and the biodistribution of experimental CNS drugs.
• Peptide & Receptor Pharmacology: Serves as a reference standard and active agent in studies targeting the bradykinin receptor pathway.
• Formulation Science: Used in developing and testing novel drug delivery systems and combination therapies intended for CNS targets.

Basic Information

Product Name	Lobradimil
CAS No.	159768-75-9
Molecular Formula	C42H68N14O11S
Molecular Weight	953.15 g/mol
Synonyms	RMP-7; Cereport; Bradykinin B2 Receptor Agonist RMP-7; [Hyp3,Tyr(Me)8]-Bradykinin; Labradimil; H-Arg-Pro-Hyp-Gly-Thi-Ser-Pro-Tyr(Me)-Arg-OH
EINECS	Contact for details

Quality Control

Our Lobradimil is manufactured under strict quality management systems to ensure the high purity and consistency required for sensitive research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, and is supplied with a detailed Certificate of Analysis (COA). We support research compliance and can provide material suitable for use under GMP guidelines for non-clinical studies, upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Biological Activity	Assayed (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.