Description

1H-Indole-3-Carbonyl Chloride, 5,6-Dimethyl- (9Ci) is a high-purity, reactive indole derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile acylating agent, enabling the efficient introduction of the 5,6-dimethylindole-3-carbonyl moiety into target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic structure.
• Peptide Mimetics & Bioconjugation: Serves as an acyl chloride for modifying peptides or creating peptide-like structures with enhanced properties.
• Material Science Research: Employed in the development of organic semiconductors, dyes, and photochromic materials due to its indole core.
• Chemical Biology Probes: Utilized to create labeled compounds or activity-based probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1H-Indole-3-Carbonyl Chloride, 5,6-Dimethyl- (9Ci)
CAS No.	159730-25-3
Molecular Formula	C12H10ClNO
Molecular Weight	219.67 g/mol
Synonyms	5,6-Dimethyl-1H-indole-3-carbonyl chloride; 5,6-Dimethylindole-3-carbonyl chloride; 1H-Indole-3-carbonyl chloride, 5,6-dimethyl-; 5,6-Dimethyl-1H-indole-3-carboxylic acid chloride; (5,6-Dimethyl-1H-indol-3-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Carbonyl Chloride, 5,6-Dimethyl- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments for non-GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and highly volatile nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.