Description

3-Cyclohexene-1-Carbonyl Fluoride, 2-Methoxy-, (1S-Cis)- (9Ci) is a chiral, fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the acyl fluoride group combined with the stereochemical control offered by its cis-configured methoxy-substituted cyclohexene scaffold. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, optically active molecules, particularly in medicinal chemistry programs targeting novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring stereospecific fluorination.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the fluorine atom and specific stereochemistry can enhance biological activity and stability.
• Advanced Material Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers with tailored properties.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to introduce the fluorocarbonyl moiety with high enantioselectivity.
• Medicinal Chemistry Probe: Utilized in drug discovery for structure-activity relationship (SAR) studies and the creation of fluorinated analogs of lead compounds.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in transition metal-catalyzed reactions, such as Suzuki or Negishi couplings, for carbon-carbon bond formation.

Basic Information

Product Name	3-Cyclohexene-1-Carbonyl Fluoride, 2-Methoxy-, (1S-Cis)- (9Ci)
CAS No.	159415-28-8
Molecular Formula	C8H11FO2
Molecular Weight	158.17 g/mol
Synonyms	(1S,2S)-2-Methoxy-3-cyclohexene-1-carbonyl fluoride; (1S-cis)-2-Methoxy-3-cyclohexenecarbonyl fluoride; 2-Methoxy-3-cyclohexene-1-carbonyl fluoride, (1S-cis)-; 3-Cyclohexene-1-carbonyl fluoride, 2-methoxy-, (1S,2S)-; (1S,2S)-rel-2-Methoxy-3-cyclohexenecarboxylic acid fluoride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC/GC), enantiomeric excess (by chiral HPLC), and identity confirmation. We adhere to strict in-process controls to guarantee batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acyl fluoride, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.