Description

Chloroacetyl Chloride-1-13C is a stable isotope-labeled derivative of chloroacetyl chloride, where the carbonyl carbon is enriched with the carbon-13 isotope. This labeled compound is essential for advanced analytical and synthetic chemistry, enabling precise metabolic pathway tracing and mechanistic studies. It is a critical reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and life science industries developing novel compounds and conducting sophisticated analytical work.

Application

• Pharmaceutical Research & Development: As a key building block for synthesizing 13C-labeled active pharmaceutical ingredients (APIs) and intermediates for drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolic Pathway Analysis: Used as a tracer in biochemical research to elucidate metabolic pathways and mechanisms of action using NMR or mass spectrometry.
• Agrochemical Development: Synthesis of isotopically labeled herbicides, pesticides, or their metabolites for environmental fate and residue analysis studies.
• Analytical Standard Production: Serves as a primary standard or precursor for certified reference materials (CRMs) used in quantitative mass spectrometry.
• Organic Synthesis: A versatile 13C-labeled acylating agent for introducing the labeled chloroacetyl group into complex molecules for structural elucidation.
• Proteomics & Peptide Chemistry: Potential use in modifying peptides or proteins with an isotopically labeled tag for detection and quantification.

Basic Information

Product Name	Chloroacetyl Chloride-1-13C
CAS No.	159301-42-5
Molecular Formula	C13CH2Cl2O
Molecular Weight	~114.94 g/mol
Synonyms	Carbon-13 Chloroacetyl Chloride; [1-13C]Chloroacetyl Chloride; 2-Chloroacetyl-1-13C Chloride; Monochloroacetyl-1-13C Chloride; Chloroacetic-1-13C Acid Chloride; 2-Chloro-1-13C-acetyl Chloride; (1-13C)Chloroacetyl Chloride
EINECS	Contact for details

Quality Control

Our Chloroacetyl Chloride-1-13C is produced under strict quality protocols to ensure high isotopic and chemical purity, critical for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR, GC-MS, and IR spectroscopy to confirm isotopic enrichment and chemical identity. Certificates of Analysis (COA) detailing isotopic purity (atom % 13C), chemical purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases, alcohols, and amines. Due to its nature as a strong acid/organic solvent and highly volatile compound, handle and store under appropriate fume hood conditions. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % 13C)	≥ 99%
Chemical Purity (GC)	≥ 98%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.