Description

1,3-Dioxolane-2-Carbonyl Chloride, 2-Methyl- is a specialized acyl chloride derivative featuring a protected carbonyl group within a dioxolane ring. This compound matters as a versatile and reactive building block for introducing the 2-methyl-1,3-dioxolan-2-yl carbonyl moiety into target molecules, enabling advanced synthetic pathways. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring acid-labile protecting groups or specific stereochemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the dioxolane group can modulate bioavailability and stability.
• Peptide & Protein Chemistry: Serves as a coupling agent or protecting group reagent in the synthesis of modified peptides and peptide mimetics.
• Material Science Research: Employed in the creation of novel polymers, dendrimers, or functionalized surfaces with tailored chemical properties.
• Organic Synthesis Reagent: Acts as a versatile acylating agent for alcohols and amines in multi-step synthetic sequences under controlled conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme activity or cellular processes.

Basic Information

Product Name	1,3-Dioxolane-2-Carbonyl Chloride, 2-Methyl-
CAS No.	159037-48-6
Molecular Formula	C5H7ClO3
Molecular Weight	150.56 g/mol
Synonyms	2-Methyl-1,3-dioxolane-2-carbonyl chloride; 2-Methyl-2-(chlorocarbonyl)-1,3-dioxolane; 1,3-Dioxolane-2-carbonyl chloride, 2-methyl-; 2-(Chlorocarbonyl)-2-methyl-1,3-dioxolane; Acetyl chloride, 2-(1,3-dioxolan-2-yl)-2-methyl-; 2-Methyl-1,3-dioxolan-2-yl carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-2-Carbonyl Chloride, 2-Methyl- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, with specifications typically meeting or exceeding 98.0% purity by HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.