Description

2'-Amino-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-5-Methyluridine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block in the development of antisense oligonucleotides, siRNA, and other advanced therapeutic nucleic acids, where precise chemical structure is paramount. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs specializing in nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides for therapeutic applications.
• siRNA and miRNA Synthesis: Enables the incorporation of specific modifications to enhance stability and efficacy of RNAi-based therapeutics.
• Diagnostic Probe Manufacturing: Utilized in creating labeled probes for genetic testing and molecular diagnostics.
• Academic and Industrial Research: Serves as a vital reagent in studies exploring nucleic acid structure, function, and novel synthetic pathways.
• Building Block for Conjugates: Facilitates the creation of nucleoside-drug or nucleoside-label conjugates for targeted delivery and imaging.

Basic Information

Product Name	2'-Amino-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-5-Methyluridine
CAS No.	158665-47-5
Molecular Formula	C31H33N3O7
Molecular Weight	559.61 g/mol
Synonyms	5-Methyl-2'-amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine; 2'-Amino-5-methyl-2'-deoxy-5'-O-DMT-uridine; 5-Methyl-2'-amino-2'-deoxyuridine 5'-O-DMT ether; DMT-2'-Amino-5-methyl-2'-deoxyuridine; 2'-NH2-5-Me-dU DMT; 2'-Amino-5-methyl-2'-deoxyuridine DMT protected; 5-Methyl-2'-amino-2'-deoxyuridine, 5'-O-(bis(4-methoxyphenyl)phenylmethyl) ether
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-5-Methyluridine is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive pharmaceutical synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.