Description

2',3'-Didehydro-2',3'-Dideoxy-5-Hydroxymethyluridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a versatile building block for the creation of novel antiviral and anticancer agents. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in nucleoside chemistry and prodrug synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral drugs, particularly those targeting viral polymerases.
• Antiviral Research: Used as a scaffold for developing potential therapeutics against a range of viruses, including HIV, hepatitis, and herpes viruses.
• Oncology Drug Discovery: Serves as a building block for creating prodrugs and targeted cancer therapies that interfere with DNA/RNA synthesis in rapidly dividing cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate mechanisms of nucleotide metabolism and incorporation.
• Prodrug Synthesis: Utilized in the design and synthesis of bioreversible derivatives to enhance drug delivery, solubility, and bioavailability.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	2',3'-Didehydro-2',3'-Dideoxy-5-Hydroxymethyluridine
CAS No.	158532-72-0
Molecular Formula	C10H12N2O5
Molecular Weight	240.21 g/mol
Synonyms	5-Hydroxymethyl-2',3'-didehydro-2',3'-dideoxyuridine; d4-5-HMU; 2',3'-Didehydro-2',3'-dideoxy-5-(hydroxymethyl)uridine; 5-(Hydroxymethyl)-2',3'-didehydro-2',3'-dideoxyuridine; NSC 722428; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Every batch of 2',3'-Didehydro-2',3'-Dideoxy-5-Hydroxymethyluridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.