Description

Adenosine, n-(1,3-Dimethyl-2-Butenyl)-, (R)- is a chemically modified adenosine derivative, specifically an N6-substituted (R)-enantiomer, which is of significant interest in medicinal chemistry and biochemical research. This compound serves as a key chiral intermediate or reference standard for the development of novel adenosine receptor modulators and other pharmaceutical agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on cardiovascular, neurological, and anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel adenosine A1, A2A, and A3 receptor agonists or antagonists.
• Biochemical Research: Used as a reference standard or ligand in receptor binding assays and enzymatic studies to investigate purinergic signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at developing new cardioprotective or neuroprotective agents.
• Process Development: Employed in the scale-up and optimization of synthetic routes for advanced active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental studies on nucleoside chemistry and chiral synthesis.
• Custom Synthesis: A starting material for the preparation of more complex, labeled (e.g., deuterated, fluorinated) or conjugated derivatives for specialized applications.

Basic Information

Product Name	Adenosine, n-(1,3-Dimethyl-2-Butenyl)-, (R)-
CAS No.	158300-15-3
Molecular Formula	C12H19N5O4
Molecular Weight	297.31 g/mol
Synonyms	(R)-N6-(1,3-Dimethyl-2-butenyl)adenosine; (R)-N6-(3-Methyl-2-butenyl)adenosine (ambiguous, verify); (R)-Prenyladenosine derivative; N6-[(R)-1,3-Dimethyl-2-butenyl]adenosine; (2R)-N6-(3-Methylbut-2-en-1-yl)adenosine; Adenosine, N6-[(1R)-1,3-dimethyl-2-butenyl]-; (R)-Isomer of N6-Prenyladenosine
EINECS	Contact for details

Quality Control

Our Adenosine, n-(1,3-Dimethyl-2-Butenyl)-, (R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment. We can support development projects requiring compliance with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% (R)-enantiomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.