Description

N4-Octadecylcytosine β-D-Arabinofuranoside is a chemically modified nucleoside analog designed for advanced research and development applications. This compound is valued for its unique structural features, which combine a long aliphatic chain with a cytosine-arabinofuranose core, offering specific interaction properties. It is primarily utilized by researchers and development teams in the pharmaceutical and biotechnology sectors, particularly in areas such as nucleic acid chemistry, prodrug development, and as a potential intermediate for novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based prodrugs and antiviral or anticancer agents.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies related to nucleoside metabolism and nucleic acid processing.
• Lipid-Conjugate Development: Its octadecyl (C18) chain makes it a candidate for creating lipid-nucleoside conjugates to enhance cellular uptake or modify pharmacokinetic properties.
• Antisense & Oligonucleotide Chemistry: Potential use as a modified monomer in the synthesis of oligonucleotides with altered stability or binding characteristics.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Material Science Exploration: Investigated for creating self-assembling nanostructures or functional materials due to its amphiphilic nature.

Basic Information

Product Name	N4-Octadecylcytosine β-D-Arabinofuranoside
CAS No.	158233-67-1
Molecular Formula	C₂₇H₄₉N₃O₅
Molecular Weight	495.70 g/mol
Synonyms	1-(3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-octadecylamino-2(1H)-pyrimidinone; 4-N-Octadecylcytosine Arabinoside; Cytosine, 4-(octadecylamino)-, β-D-arabinofuranoside; N4-Stearylcytosine Arabinoside; Octadecylcytosine Arabinofuranoside; Ara-C18-Cyt; C18-Ara-Cyt
EINECS	Contact for details

Quality Control

Our N4-Octadecylcytosine β-D-Arabinofuranoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure full traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.