Description

2'-Deoxy-8-Methylthio-Guanosine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and a key intermediate in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Proteomics & Genomics: Serves as a modified building block for oligonucleotide synthesis in probing nucleic acid structure and function.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic candidates with improved efficacy and selectivity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2'-Deoxy-8-Methylthio-Guanosine
CAS No.	157946-92-4
Molecular Formula	C11H15N5O4S
Molecular Weight	313.33 g/mol
Synonyms	8-(Methylthio)-2'-deoxyguanosine; 2'-Deoxy-8-(methylthio)guanosine; 8-Methylmercapto-2'-deoxyguanosine; 8-Methylthio-2'-deoxyguanosine; 2'-Deoxy-8-methylmercaptoguanosine; dG(SMe); 8-SMe-dG; 2'-Deoxyguanosine, 8-(methylthio)-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-8-Methylthio-Guanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.