Description

1-(6-(4-Azido-2,3,5,6-Tetrafluorobenzamido)Hexyl)-3-Cyclohexylcarbodiimide is a specialized heterobifunctional crosslinking agent designed for advanced bioconjugation and materials science applications. This compound matters because it uniquely combines a photoactivatable aryl azide group with a carbodiimide moiety, enabling sequential and controlled coupling reactions under mild conditions. It is primarily needed by researchers and manufacturers in pharmaceutical development, proteomics, and polymer chemistry for creating stable, site-specific conjugates of biomolecules and synthetic materials.

Application

• Bioconjugation and Protein Labeling: For covalently attaching fluorophores, affinity tags, or other probes to proteins, antibodies, and peptides via amine or carboxyl groups.
• Surface Immobilization and Biochip Fabrication: Used to functionalize sensor surfaces, microarrays, and nanoparticles with biomolecules for diagnostic and biosensing applications.
• Polymer Crosslinking and Modification: Employed in the synthesis and modification of hydrogels, dendrimers, and other polymeric materials to introduce specific functional groups or enhance material properties.
• Chemical Biology and Probe Development: Serves as a key reagent in the synthesis of activity-based probes (ABPs) and photoaffinity labels for studying protein function and interactions.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the development of novel linker technologies for connecting cytotoxic payloads to monoclonal antibodies.
• Materials Science: Applied in the creation of advanced composite materials and coatings with tailored interfacial properties.

Basic Information

Product Name	1-(6-(4-Azido-2,3,5,6-Tetrafluorobenzamido)Hexyl)-3-Cyclohexylcarbodiimide
CAS No.	157918-73-5
Molecular Formula	C₂₀H₂₄F₄N₆O
Molecular Weight	440.44 g/mol
Synonyms	NSC 339242; 1-(6-((4-Azido-2,3,5,6-tetrafluorobenzoyl)amino)hexyl)-3-cyclohexylcarbodiimide; 3-Cyclohexyl-1-[6-[[(4-azido-2,3,5,6-tetrafluorophenyl)carbonyl]amino]hexyl]carbodiimide; Heterobifunctional Crosslinker (Azide/Carbodiimide); Carbodiimide-PEG6-Azide (Tetrafluorinated aryl azide variant); Photoactivatable Carbodiimide Reagent
EINECS	Contact for details

Quality Control

Our 1-(6-(4-Azido-2,3,5,6-Tetrafluorobenzamido)Hexyl)-3-Cyclohexylcarbodiimide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity suitable for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.