Description

N(6)-(3-Isothiocyanatobenzyl)Adenosine-5'-n-Methyluronamide is a high-purity, synthetic adenosine derivative designed for advanced biochemical research and development. This compound serves as a critical tool molecule for studying adenosine receptor signaling pathways and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cardiology, neurology, and immunology.

Application

• Biochemical Research: A key ligand and precursor for investigating adenosine A1, A2A, A2B, and A3 receptor subtypes.
• Pharmaceutical Development: Used in the synthesis and screening of novel adenosine receptor agonists and antagonists for therapeutic applications.
• Diagnostic Probe Synthesis: Serves as a core structure for creating labeled probes (e.g., fluorescent, radioactive) for receptor binding assays and imaging studies.
• Signal Transduction Studies: Essential for elucidating the role of adenosine receptors in cellular processes like inflammation, vasodilation, and neurotransmission.
• High-Throughput Screening (HTS): Employed as a reference standard in HTS campaigns to identify new drug candidates targeting purinergic signaling.
• Academic & Institutional Research: Supports fundamental research in molecular pharmacology and medicinal chemistry.

Basic Information

Product Name	N(6)-(3-Isothiocyanatobenzyl)Adenosine-5'-n-Methyluronamide
CAS No.	157848-36-7
Molecular Formula	C19H21N7O5S
Molecular Weight	459.48 g/mol
Synonyms	N6-(3-Isothiocyanatobenzyl)adenosine-5'-N-methyluronamide; 5'-N-Methylcarboxamidoadenosine-6-yl-isothiocyanate; MRS 5147; 6-[(3-Isothiocyanatobenzyl)amino]-9-[(2R,3R,4S,5S)-5-(methylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purine; 3-IB-MECA isothiocyanate derivative; Adenosine A3 receptor ligand isothiocyanate; N6-(3-Isothiocyanatobenzyl)-5'-N-methylcarbamoyladenosine
EINECS	Contact for details

Quality Control

Our N(6)-(3-Isothiocyanatobenzyl)Adenosine-5'-n-Methyluronamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material for GLP-compliant research upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.