Description

Perifosine (Krx-0401) is a synthetic alkylphospholipid and a potent, orally active small molecule inhibitor of the Akt signaling pathway. This compound is a key research tool and investigational agent for targeting cellular proliferation and survival mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology and signal transduction research. The product is supplied under the identifier CAS NO 157716-52-4.

Application

• Oncology Research: Investigated as a potential therapeutic agent in preclinical and clinical studies for various cancers, including multiple myeloma, colorectal cancer, and melanoma.
• Signal Transduction Studies: Used as a selective inhibitor to study the role of the PI3K/Akt/mTOR pathway in cell growth, apoptosis, and metabolism.
• Drug Discovery & Development: Serves as a reference standard, lead compound, or pharmacologic tool in high-throughput screening and compound library development.
• Biochemical Assays: Employed in in vitro enzymatic assays to evaluate Akt kinase inhibition and downstream effects.
• Academic Research: Utilized in university and institutional labs for fundamental research into lipid-mediated signaling and cancer biology.
• Pharmaceutical Intermediates: Acts as a critical intermediate in the synthesis of related alkylphospholipid analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Perifosine (Krx-0401)
CAS No.	157716-52-4
Molecular Formula	C25H52NO4P
Molecular Weight	461.66 g/mol
Synonyms	KRX-0401; D-21266; Perifosin; NSC 639966; Octadecyl-(1,1-dimethylpiperidinio-4-yl)-phosphate; 1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate; Erythro-1-(octadecyloxy)-3-(4-(piperidyl)butane phosphoric acid)
EINECS	Contact for details

Quality Control

Our Perifosine (Krx-0401) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (NMR, MS), and residual solvent analysis to ensure it meets high-purity standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.