Description

Fmoc-o-Benzyl-L-Seryl Chloride CAS NO 157506-72-4 is a protected amino acid derivative specifically engineered for peptide synthesis. This compound is a critical reagent for the controlled introduction of serine residues while preventing unwanted side reactions during solid-phase and solution-phase peptide assembly. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require high-purity, reliable building blocks for complex peptide and protein mimetic synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated, sequential assembly of peptides on resin, particularly for incorporating protected serine.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments in solution.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic or drug delivery applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic and R&D Laboratories: Used in fundamental research exploring protein structure-function relationships and novel synthetic methodologies.

Basic Information

Product Name	Fmoc-o-Benzyl-L-Seryl Chloride
CAS No.	157506-72-4
Molecular Formula	C25H22ClNO5
Molecular Weight	451.90 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-benzyl-L-serine chloride; Fmoc-Ser(Bzl)-Cl; Fmoc-O-benzyl-L-serine chloride; N-Fmoc-O-benzyl-L-serinyl chloride; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(benzyloxy)propanoyl chloride; Fmoc-L-Ser(Bzl)-Cl; Fmoc-Ser(OBzl)-Cl
EINECS	Contact for details

Quality Control

Our Fmoc-o-Benzyl-L-Seryl Chloride is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and reactive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.