Description

5-o-Carboranyl-1-(2-Deoxy-2-Fluoro-Arabinofuranosyl)Uracil is a sophisticated boron-containing nucleoside analog, representing a significant advancement in the field of medicinal chemistry and radiopharmaceuticals. Its core value lies in its unique molecular architecture, which combines a carborane cage for boron neutron capture therapy (BNCT) with a fluorinated sugar moiety for enhanced metabolic stability and targeting. This compound is essential for researchers and developers in pharmaceutical R&D, oncology therapeutics, and diagnostic imaging, particularly for the development of next-generation cancer treatments.

Application

• Boron Neutron Capture Therapy (BNCT): Serves as a key boron delivery agent for targeted cancer treatment, leveraging the high neutron capture cross-section of the 10B isotope.
• Oncological Research: Used as a critical intermediate or active pharmaceutical ingredient (API) in the development of novel anti-cancer drugs and targeted therapies.
• Radiopharmaceuticals: Acts as a precursor for the synthesis of fluorinated compounds used in Positron Emission Tomography (PET) imaging agents.
• Medicinal Chemistry Studies: Employed in structure-activity relationship (SAR) studies to investigate the impact of carboranyl and fluorinated sugar modifications on biological activity.
• Nucleoside Analog Development: Provides a platform for creating modified nucleosides with potential antiviral or anticancer properties.
• Academic & Institutional Research: Utilized in biochemical and pharmacological research exploring novel mechanisms of action for boronated compounds.

Basic Information

Product Name	5-o-Carboranyl-1-(2-Deoxy-2-Fluoro-Arabinofuranosyl)Uracil
CAS No.	157444-53-6
Molecular Formula	C11H17B10FN2O5
Molecular Weight	~ 394.14 g/mol (Contact for exact details)
Synonyms	5-o-Carboranyl-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; 5-(1,2-Dicarba-closo-dodecaboran-1-yl)-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; 5-Carboranyl-FAU; Boronated FMAU; 5-(o-Carboran-1-yl)-2'-deoxy-2'-fluoroarabinouridine; BNCT Nucleoside Analog; 157444-53-6; 5-o-Carboranyl-2'-F-ara-U
EINECS	Contact for details

Quality Control

We supply 5-o-Carboranyl-1-(2-Deoxy-2-Fluoro-Arabinofuranosyl)Uracil to high-purity standards suitable for research and development applications. Our products undergo rigorous quality testing including HPLC, NMR, and MS analysis to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical specifications. We adhere to strict quality management protocols to ensure reliable and reproducible performance in your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.