Description

2,3,4-Trifluorobenzoyl Chloride is a high-purity fluorinated aromatic acid chloride building block. This compound is critical for introducing the 2,3,4-trifluorobenzoyl moiety into target molecules, enabling precise modification of their physical and chemical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluorobenzoyl group enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer chains, improving material properties like chemical resistance and thermal stability.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and amide bond formation in complex molecule construction within R&D laboratories.
• Fluorinated Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2,3,4-Trifluorobenzoyl Chloride
CAS No.	157373-08-5
Molecular Formula	C7H2ClF3O
Molecular Weight	194.54 g/mol
Synonyms	2,3,4-Trifluorobenzoic acid chloride; Benzoyl chloride, 2,3,4-trifluoro-; 2,3,4-Trifluorobenzoic acid chloride; 2,3,4-Trifluorobenzoyl chloride; 2,3,4-Trifluoro-benzoyl chloride; α,2,3,4-Tetrafluorotoluene (obsolete); 157373-08-5 (CAS); TFBC
EINECS	Contact for details

Quality Control

Our 2,3,4-Trifluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts with water, strong acids, and bases. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.