Description

22-Dehydro 25-Hydroxy Cholesterol 3-Acetate is a high-purity, synthetic sterol derivative of significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of vitamin D analogs and other bioactive steroid molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic studies, drug discovery, and the production of specialized reference standards.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of vitamin D3 metabolites and analogs, such as calcifediol.
• Biochemical Research: Used as a reference standard and reagent in studies of cholesterol metabolism, liver enzyme activity (e.g., CYP27A1), and sterol biosynthesis pathways.
• Drug Discovery: Serves as a building block for developing novel therapeutic agents targeting nuclear receptors and metabolic diseases.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for the qualitative and quantitative analysis of sterol compounds.

Basic Information

Product Name	22-Dehydro 25-Hydroxy Cholesterol 3-Acetate
CAS No.	157171-88-5
Molecular Formula	C₂₉H₄₈O₃
Molecular Weight	444.70 g/mol
Synonyms	(25R)-3β-Acetoxy-22,23-didehydro-5-cholesten-25-ol; 25-Hydroxycholesta-5,22-dien-3β-yl acetate; 22-Dehydro-25-hydroxycholesterol 3-acetate; 25-Hydroxy-22-dehydrocholesterol acetate; 3β-Acetoxy-22-dehydro-25-hydroxycholesterol; Cholesta-5,22-dien-3β-ol, 25-hydroxy-, acetate; 25-Hydroxycholesta-5,22-dien-3β-yl acetate
EINECS	Contact for details

Quality Control

Our 22-Dehydro 25-Hydroxy Cholesterol 3-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.