Description

2-(3,5-Difluorophenyl)Ethanoyl Chloride is a high-purity, reactive aromatic acid chloride intermediate essential for advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 2-(3,5-difluorophenyl)acetyl moiety, a key structural motif in modern pharmaceuticals and agrochemicals. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of novel polymers and advanced organic materials with specific electronic or optical properties.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs producing custom fine chemicals for client projects.
• Fluorinated Compound Libraries: Key reactant for generating fluorinated compound libraries used in high-throughput screening for drug discovery.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Ethanoyl Chloride
CAS No.	157033-24-4
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2-(3,5-Difluorophenyl)acetyl chloride; 3,5-Difluorophenylacetyl chloride; 2-(3,5-Difluorophenyl)acetic acid chloride; (3,5-Difluorophenyl)acetyl chloride; α-Chloro-3,5-difluoroacetophenone; 3,5-Difluoro-ω-chloroacetophenone; 2-(3,5-Difluorophenyl)-1-chloroethanone
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Ethanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for scale-up and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and handled under dry conditions to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Assay (Titration)	97.0 - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.