Description

(2,5-Difluoro-Phenyl)-Acetyl Chloride is a high-purity, reactive organic intermediate essential for advanced chemical synthesis. Its value lies in its role as a key acylating agent for introducing the (2,5-difluorophenyl)acetyl moiety, a crucial building block in modern pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluorophenyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers and polymers with specific fluorinated aromatic properties for advanced materials.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs performing custom synthesis and scale-up services.
• Fluorinated Liquid Crystal Precursor: Used in the development of fluorinated components for electronic display technologies.

Basic Information

Product Name	(2,5-Difluoro-Phenyl)-Acetyl Chloride
CAS No.	157033-23-3
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2',5'-Difluorophenacyl Chloride; (2,5-Difluorophenyl)acetyl Chloride; 2,5-Difluorophenylacetyl Chloride; 2-(2,5-Difluorophenyl)acetyl Chloride; α-Chloro-2,5-difluoroacetophenone; 2,5-Difluoro-ω-chloroacetophenone; 1-Chloro-2-(2,5-difluorophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our (2,5-Difluoro-Phenyl)-Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from moisture, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.