Description

8-Piperidinoadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is a high-purity, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical and pharmacological research. This compound matters as a potent and selective activator of protein kinase A (PKA), offering superior resistance to hydrolysis by phosphodiesterases compared to standard cAMP, which ensures prolonged and stable intracellular signaling. It is essential for researchers and developers in pharmaceutical discovery, neurobiology, and cardiovascular research who require precise tools to study cAMP-mediated signal transduction pathways.

Application

• Biochemical Research: As a stable, cell-permeable activator for studying cAMP-dependent protein kinase (PKA) signaling cascades in vitro and in cell-based assays.
• Drug Discovery & Pharmacology: A critical reference standard and tool compound for screening and validating novel therapeutics targeting G-protein-coupled receptors (GPCRs) and downstream effectors.
• Neuroscience Studies: Investigation of synaptic plasticity, neurotransmitter release, and long-term potentiation (LTP) mechanisms influenced by cAMP-PKA pathways.
• Cardiovascular Research: Exploration of cardiac contractility, ion channel regulation, and vascular smooth muscle relaxation processes.
• Metabolic Disorder Research: Studying the role of cAMP in insulin secretion, gluconeogenesis, and lipid metabolism for diabetes and obesity-related research.
• Academic & Institutional R&D: A key reagent for fundamental research in cellular signaling, molecular biology, and physiology at universities and research institutes.

Basic Information

Product Name	8-Piperidinoadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt
CAS No.	156816-35-2
Molecular Formula	C15H21N6O5PSNa
Molecular Weight	467.40 g/mol
Synonyms	8-Piperidino-cAMPS, Sp-isomer, sodium salt; 8-PIP-cAMPS; Sp-8-Piperidino-adenosine-3',5'-cyclic monophosphorothioate sodium salt; Sp-8-Piperidino-cAMPS; cAMP analog, Sp-8-PIP; Protein Kinase A Activator, Sp-8-Piperidino-cAMPS; 8-(Piperidin-1-yl)adenosine-3',5'-cyclic monophosphorothioate, Sp-isomer, sodium salt
EINECS	Contact for details

Quality Control

Our 8-Piperidinoadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.