Description

3'-Azido-3'-Deoxythymidine Triphosphate Distearoylglycerol is a specialized nucleotide-lipid conjugate designed for advanced biochemical and pharmaceutical research. This compound is critical for applications requiring the targeted delivery or modification of nucleic acids, offering a unique combination of nucleotide activity and lipid solubility. It is primarily utilized by researchers and developers in the fields of nucleic acid therapeutics, prodrug development, and targeted drug delivery systems. The product is supplied to meet the stringent purity requirements of high-end life science applications.

Application

• Prodrug Synthesis: Serves as a key intermediate in the development of nucleotide-based prodrugs for antiviral and anticancer therapies.
• Lipid Nanoparticle (LNP) Formulation: Used as a functionalized lipid component to enhance the encapsulation and delivery of mRNA, siRNA, or other genetic materials.
• Bioconjugation & Labeling: Enables the site-specific labeling or conjugation of biomolecules via its azido group for click chemistry applications.
• Enzymatic Studies: Acts as a substrate or inhibitor in studies involving DNA polymerases and reverse transcriptases to investigate mechanism of action.
• Targeted Drug Delivery: Facilitates the development of ligand-directed therapeutics by combining nucleotide pharmacology with lipid-based targeting moieties.
• Research Tool: Provides a critical reagent for academic and industrial research into novel drug delivery mechanisms and nucleic acid chemistry.

Basic Information

Product Name	3'-Azido-3'-Deoxythymidine Triphosphate Distearoylglycerol
CAS No.	156705-00-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	AZT-TP Distearoylglycerol; 3'-Azido-3'-deoxythymidine 5'-triphosphate 1,2-distearoyl-sn-glycerol ester; AZT Triphosphate Lipid Conjugate; Stavudine Triphosphate Lipid Prodrug (related analog); Nucleoside Triphosphate-Lipid Conjugate; 3'-N3-dTTP-DSG
EINECS	Contact for details

Quality Control

Every batch of 3'-Azido-3'-Deoxythymidine Triphosphate Distearoylglycerol is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.