Description

Amythiamicin C CAS NO 156620-47-2 is a thiopeptide antibiotic belonging to the amythiamicin family, characterized by its complex macrocyclic structure containing thiazole and dehydroalanine residues. This compound is of significant interest in pharmaceutical research and development due to its potent antibacterial activity, particularly against Gram-positive pathogens. It serves as a valuable reference standard and a key intermediate for researchers in medicinal chemistry, microbiology, and antibiotic discovery programs.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of amythiamicin compounds in research and quality control laboratories.
• Antibiotic Research: Acts as a critical biochemical tool for studying the mechanism of action of thiopeptide antibiotics and their interaction with bacterial ribosomes.
• Medicinal Chemistry Intermediate: Serves as a starting material or building block for the synthesis of novel antibiotic analogs and derivatives with improved properties.
• Microbiological Studies: Employed in in vitro assays to evaluate antibacterial spectrum, minimum inhibitory concentration (MIC), and resistance mechanisms.
• Biochemical Research: Utilized in studies exploring protein synthesis inhibition and the development of new anti-infective agents.

Basic Information

Product Name	Amythiamicin C
CAS No.	156620-47-2
Molecular Formula	C58H85N13O15S6
Molecular Weight	~1364.8 g/mol
Synonyms	Amythiamicin C; Antibiotic BM782 alpha1; BM 782 alpha1; L 156,620; Thiopeptide BM782 alpha1; (3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42S,45S)-45-[[(2S)-2-Amino-2-carboxyethyl]thio]-39-(2-amino-2-oxoethyl)-6,15,24,33,42-pentakis(3-amino-3-oxopropyl)-3,12,21,30-tetrakis(carboxymethyl)-27-[(1E)-3-(1,3-thiazol-4-yl)-2-propenoyl]-36-(hydroxymethyl)-4,7,10,13,16,19,22,25,28,31,34,37,40,46-tetradecaoxo-9-(2-oxoethyl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,47-tetradecazacyclopentapentacontane-18-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of Amythiamicin C is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.