Description

Amythiamicin D CAS NO 156620-46-1 is a thiopeptide antibiotic compound belonging to the amythiamicin class. This molecule is of significant interest for its potent biological activity, particularly as a lead structure in antimicrobial research and development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in the discovery of novel antibacterial agents and the study of bacterial protein synthesis inhibition.

Application

• Antibacterial Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of new antibiotics targeting drug-resistant bacteria.
• Mechanistic Studies: Used in biochemical and microbiological assays to investigate the inhibition of bacterial translation, specifically targeting the GTPase-associated region of the ribosome.
• Structure-Activity Relationship (SAR) Analysis: Employed as a core scaffold for chemical modification to optimize potency, spectrum, and pharmacokinetic properties in medicinal chemistry programs.
• In-vitro Biological Screening: Utilized as a positive control or test compound in high-throughput screening campaigns against Gram-positive bacterial pathogens.
• Academic Research: Fundamental studies in organic synthesis, natural product chemistry, and molecular biology to understand thiopeptide biosynthesis and mode of action.

Basic Information

Product Name	Amythiamicin D
CAS No.	156620-46-1
Molecular Formula	C42H49N13O10S6
Molecular Weight	1080.3 g/mol
Synonyms	Amythiamicin D; Antibiotic A 10255 D; GE 2270 D; Thiopeptide GE2270D; L 156620-46-1; (2S)-2-[[(2S,5R,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S)-11,14,17,23,26,29,32,35-Octakis(1-methylethyl)-5,8,20,38-tetramethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49-hexadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48-hexadecazapentacontan-50-yl]oxy]-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our Amythiamicin D is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and microbiological sterility checks where applicable. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade material specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Bacterial Endotoxins	<1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.