Description

2',3'-Dithiouridine is a chemically modified nucleoside derivative, specifically a thiolated analog of uridine. This compound is of significant interest in biochemical and pharmaceutical research due to its unique sulfur-containing structure, which can impart distinct reactivity and binding properties. It serves as a critical building block and research tool for scientists in nucleic acid chemistry, medicinal chemistry, and drug discovery, particularly in the development of novel oligonucleotide therapeutics and probes.

Application

• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support precursor for incorporating thiol modifications into DNA or RNA strands.
• Medicinal Chemistry & Drug Discovery: Acts as a key intermediate in the research and development of nucleoside-based antiviral or anticancer agents.
• Bioconjugation & Labeling: The thiol groups enable site-specific conjugation with maleimides, iodoacetamides, or other reagents for attaching fluorophores, biotin, or other functional tags.
• Structural Biology Studies: Employed to investigate RNA structure, folding, and protein-RNA interactions through cross-linking or metal coordination.
• Catalysis Research: Serves as a model compound or ligand in studies of ribozyme mechanisms and metalloenzyme mimics.
• Diagnostic Probe Development: Utilized in the design of sensitive and specific molecular probes for detecting nucleic acid sequences.

Basic Information

Product Name	2',3'-Dithiouridine
CAS No.	156592-92-6
Molecular Formula	C9H12N2O5S2
Molecular Weight	292.33 g/mol
Synonyms	2',3'-Dithiouridine; 2',3'-Dithio-uridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-thiolanyl]-2,4(1H,3H)-pyrimidinedithione; Uridine, 2,3-dithio-; 2-Thio-3-thiouridine
EINECS	Contact for details

Quality Control

Our 2',3'-Dithiouridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to meet the exacting requirements of pharmaceutical and biotechnology research. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.