Description

5-Isothiocyanonicotine is a specialized organic compound belonging to the nicotine analog family, characterized by the presence of a reactive isothiocyanate functional group. This structural feature makes it a valuable intermediate for the synthesis of novel chemical probes and ligands used in biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical development companies focused on neuroscience, receptor studies, and the development of diagnostic tools.

Application

• Biochemical Research: Acts as a key intermediate for synthesizing affinity labels and photoaffinity probes targeting nicotinic acetylcholine receptors (nAChRs).
• Pharmaceutical Development: Used in the design and synthesis of novel drug candidates for neurological disorders and addiction research.
• Diagnostic Agent Synthesis: Serves as a precursor for developing radiolabeled or fluorescent tracers for receptor mapping and imaging studies.
• Chemical Biology: Employed in activity-based protein profiling (ABPP) to study enzyme function and identify novel drug targets.
• Agrochemical Research: Investigated as a synthetic intermediate for novel compounds with potential insecticidal or pest control properties.

Basic Information

Product Name	5-Isothiocyanonicotine
CAS No.	156577-11-6
Molecular Formula	C11H11N3S
Molecular Weight	217.29 g/mol
Synonyms	5-Isothiocyanonicotine; Nicotine-5-isothiocyanate; 5-Isothiocyanato-3-(1-methyl-2-pyrrolidinyl)pyridine; 3-[(2S)-1-Methylpyrrolidin-2-yl]-5-isothiocyanatopyridine; 5-Pyridyl isothiocyanate nicotine derivative
EINECS	Contact for details

Quality Control

Our 5-Isothiocyanonicotine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and custom purity grades can be accommodated upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.