Description

2-Chloro-2'-Deoxy-2'-Fluoroadenosine is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This modified adenosine derivative serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Antiviral Drug Development: Investigated for its potential incorporation into oligonucleotides or prodrugs targeting viral polymerases.
• Labeled Compound Synthesis: Can be used as a starting material for preparing isotopically labeled (e.g., 13C, 15N) versions for metabolic tracing studies.
• Academic Research: Employed in universities and research institutes for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	2-Chloro-2'-Deoxy-2'-Fluoroadenosine
CAS No.	156357-18-5
Molecular Formula	C10H11ClFN5O3
Molecular Weight	303.68 g/mol
Synonyms	2-Chloro-2'-deoxy-2'-fluoroadenosine; 2-Chloro-9-(2-deoxy-2-fluoro-β-D-erythro-pentofuranosyl)adenine; 2-Cl-2'-F-ara-A; 2-Chloro-2'-fluoro-2'-deoxyadenosine; 2-Chloro-2'-fluoro-2'-deoxy-β-D-adenosine; 9-(2-Deoxy-2-fluoro-β-D-erythro-pentofuranosyl)-2-chloroadenine; Adenosine, 2-chloro-2'-deoxy-2'-fluoro-
EINECS	Contact for details

Quality Control

Our 2-Chloro-2'-Deoxy-2'-Fluoroadenosine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.