Description

1,3-Dioxino4,5,6-Hiindolizine, 8-Azidooctahydro-9-(Methoxymethoxy)-2,2-Dimethyl-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)- is a complex, high-purity heterocyclic compound featuring a unique indolizine core functionalized with an azido group and a methoxymethoxy protecting group. This specific molecular architecture makes it a critical advanced intermediate in sophisticated organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), especially those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with modified pharmacokinetic properties.
• Chemical Biology Probes: The azido functional group allows for bioorthogonal "click chemistry" applications, enabling the labeling and study of biological systems.
• Advanced Organic Synthesis: Employed in multi-step synthetic routes to construct complex natural product analogs or novel heterocyclic frameworks.
• Agrochemical Research: Potential intermediate in the development of new generation herbicides or insecticides with novel modes of action.
• Academic Research: Used in university and institutional labs for methodological development and exploring new chemical transformations.

Basic Information

Product Name	1,3-Dioxino4,5,6-Hiindolizine, 8-Azidooctahydro-9-(Methoxymethoxy)-2,2-Dimethyl-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	156205-93-5
Molecular Formula	C₁₄H₂₂N₄O₄
Molecular Weight	310.35 g/mol
Synonyms	8-Azidooctahydro-9-(methoxymethoxy)-2,2-dimethyl-3aH-[1,3]dioxino[4,5,6-hi]indolizine; (3aα,8α,9β,9aβ,9bα)-8-Azidooctahydro-9-(methoxymethoxy)-2,2-dimethyl-3aH-[1,3]dioxino[4,5,6-hi]indolizine; 1,3-Dioxino[4,5,6-hi]indolizine, 8-azidooctahydro-9-(methoxymethoxy)-2,2-dimethyl-, (3aα,8α,9β,9aβ,9bα)-; CAS 156205-93-5; Advanced Indolizine Intermediate; Azido-functionalized Heterocycle.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider keeping the material under an inert atmosphere (e.g., nitrogen or argon) in a freezer (-20°C) to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.