Description

Losartan-Hydrochlorothiazide Mixture CAS NO 156154-37-9 is a fixed-dose combination of two antihypertensive agents, designed for the effective management of hypertension. This synergistic mixture combines the angiotensin II receptor blocker (ARB) losartan with the thiazide diuretic hydrochlorothiazide, offering a convenient and potent therapeutic option. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular medications.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of combination tablets for the treatment of hypertension (high blood pressure).
• Clinical Research: Serves as a reference standard or raw material in pharmacokinetic, pharmacodynamic, and bioequivalence studies.
• Drug Development: Used in pre-formulation studies and the development of new fixed-dose combination drug products.
• Generic Drug Manufacturing: A critical component for companies producing generic versions of branded combination antihypertensive drugs.
• Analytical Testing: Employed as a system suitability standard or calibrant in quality control laboratories for HPLC, UV, and other analytical methods.

Basic Information

Product Name	Losartan-Hydrochlorothiazide Mixture
CAS No.	156154-37-9
Molecular Formula	C22H23ClKN6O • C7H8ClN3O4S2
Molecular Weight	461.01 (Losartan Potassium) • 297.73 (Hydrochlorothiazide)
Synonyms	Losartan Potassium and Hydrochlorothiazide; Losartan/HCTZ; Cozaar-HCT; Hyzaar; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt mixture with 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Losartan K/HCTZ; Fixed-Dose Antihypertensive Combination
EINECS	Contact for details

Quality Control

Our Losartan-Hydrochlorothiazide Mixture is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure compliance with relevant pharmacopeial standards (e.g., USP, EP). A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to reference spectra
Identification (HPLC)	Retention time corresponds to reference standard
Assay (Losartan Potassium)	98.0% - 102.0% (on anhydrous basis)
Assay (Hydrochlorothiazide)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.