Description

Lurtotecan Hydrochloride CAS NO 155773-58-3 is a potent topoisomerase I inhibitor used as a key pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critical for the research and development of novel chemotherapeutic agents targeting various solid tumors. It is primarily utilized by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in oncology drug discovery and advanced therapeutic formulation.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of injectable chemotherapeutic drugs.
• Critical intermediate in the synthesis of advanced oncology compounds and next-generation topoisomerase inhibitors.
• Reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Key material for preclinical and clinical research studying mechanisms of topoisomerase I inhibition.
• Used in the development of combination therapies and targeted drug delivery systems.
• Essential component for stability studies and formulation optimization of anticancer medications.

Basic Information

Product Name	Lurtotecan Hydrochloride
CAS No.	155773-58-3
Molecular Formula	C₂₃H₂₃N₃O₄ • HCl
Molecular Weight	449.91 g/mol
Synonyms	Lurtotecan HCl; 7-(4-Methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin hydrochloride; GI-147211C; (S)-10,11-Methylenedioxy-20-camptothecin 7-(4-methyl-1-piperazinyl)methyl hydrochloride; Camptothecin, 7-[(4-methyl-1-piperazinyl)methyl]-10,11-(methylenedioxy)-, hydrochloride, (S)-; Lurtotecan monohydrochloride
EINECS	Contact for details

Quality Control

Our Lurtotecan Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.