Description

2-(2-(2,4-Difluorophenyl)-2-Hydroxy-1-Methyl-3-(1H-1,2,4-Triazol-1-Yl)Propyl)-4-(4-(2,2,3,3- Tetrafluoropropoxy)Phenyl)- 3(2H,4H)-1,2,4-Triazolone is a sophisticated triazole derivative, a key advanced intermediate in the synthesis of high-value active pharmaceutical ingredients (APIs). Its complex molecular architecture, featuring difluorophenyl and tetrafluoropropoxy groups, is engineered to impart specific biological activity and metabolic stability. This compound is essential for research and development chemists and manufacturers in the pharmaceutical industry, particularly those focused on developing novel antifungal and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel triazole-based antifungal APIs.
• Agrochemical Research: Serves as a precursor in the development of new-generation fungicides and plant protection agents.
• Chemical Synthesis: Used in organic synthesis for constructing complex molecules with triazole and fluorinated aromatic moieties.
• Biochemical Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Development: Utilized in scaling up and optimizing manufacturing routes for target drug molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	2-(2-(2,4-Difluorophenyl)-2-Hydroxy-1-Methyl-3-(1H-1,2,4-Triazol-1-Yl)Propyl)-4-(4-(2,2,3,3- Tetrafluoropropoxy)Phenyl)- 3(2H,4H)-1,2,4-Triazolone
CAS No.	155432-64-7
Molecular Formula	C24H21F6N5O3
Molecular Weight	541.45 g/mol
Synonyms	Fluconazole Intermediate; TAK-187 Intermediate; 2-(2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4H-1,2,4-triazol-3(2H)-one; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-{4-[(2,2,3,3-tetrafluoropropoxy)methyl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one-4-yl)-1,1,1-trifluoro-2-butanol (related isomer); UNII-7V31C1688S; Efinaconazole related compound; Antifungal triazolone derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, supporting development from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.