Description

1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4S,5R)- (9Ci) is a high-value, stereochemically defined chiral building block used in advanced organic synthesis. This compound is critical for introducing protected diol and carbonyl functionalities in a stereocontrolled manner, enabling the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where stereoselectivity impacts biological activity.
• Asymmetric Catalysis Research: Serves as a precursor or ligand component in the development of new catalytic systems.
• Natural Product Synthesis: Employed in the total synthesis of natural products containing dioxolane or similar acetal-protected diol motifs.
• Polymer Chemistry: Can be used to introduce functional, chiral monomers for specialty polymer applications.
• Chemical Biology Probes: Useful for creating labeled or modified compounds for studying biological mechanisms.

Basic Information

Product Name	1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4S,5R)- (9Ci)
CAS No.	155322-89-7
Molecular Formula	C7H11ClO3
Molecular Weight	178.62 g/mol
Synonyms	(4S,5R)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (4S-cis)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic acid chloride; (4S,5R)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic acid chloride; (4S,5R)-2,2,5-Trimethyl-[1,3]dioxolane-4-carbonyl chloride; (4S,5R)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; Chiral Dioxolane Carbonyl Chloride; (4S,5R)-TMDO-COCl
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4S,5R)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.