Description

9-(3,3-Dimethyl-5-Phosphonopentyl)Guanine is a synthetic purine nucleoside analogue with a unique phosphonate side chain. This compound is of significant interest in pharmaceutical research and development, particularly as a potential antiviral or anticancer agent due to its structural similarity to natural nucleotides. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of novel therapeutic candidates and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleotide-based drugs targeting viral infections and oncology.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Antiviral Agent Development: Investigated for its potential activity against DNA viruses due to its guanine analogue structure.
• Prodrug Synthesis: Acts as a precursor for the development of phosphonate prodrugs with enhanced bioavailability.
• Labeled Compound Synthesis: Can be used to create radiolabeled or fluorescently tagged versions for tracing and diagnostic applications.
• Polymerase Studies: Employed in research to study the mechanism and fidelity of DNA polymerases.

Basic Information

Product Name	9-(3,3-Dimethyl-5-Phosphonopentyl)Guanine
CAS No.	155270-69-2
Molecular Formula	C12H19N5O4P
Molecular Weight	328.29 g/mol
Synonyms	9-[(5-Phosphono-3,3-dimethylpentyl)]guanine; PMEG precursor; (3,3-Dimethyl-5-phosphonopentyl)guanine; Guanine, 9-[3,3-dimethyl-5-(phosphono)pentyl]-; Acyclic nucleoside phosphonate analogue; ANP guanine derivative
EINECS	Contact for details

Quality Control

Our 9-(3,3-Dimethyl-5-Phosphonopentyl)Guanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment. Handle and store under an inert atmosphere for optimal shelf life.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.