Description

5-Benzoxazolecarbonyl Chloride, 2,3-Dihydro-3-Methyl-2-Oxo- (9Ci) is a high-purity, reactive heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the benzoxazolone pharmacophore, enabling the development of novel compounds with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating potential drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the benzoxazolone moiety can enhance efficacy and selectivity.
• Material Science Research: Serves as a monomer or coupling agent in the synthesis of specialized polymers and functional materials with unique optical or electronic properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks via amidation and esterification reactions.
• Bioconjugation Chemistry: Potential use in modifying biomolecules (e.g., peptides, proteins) for diagnostic or therapeutic applications due to its reactive acyl chloride group.

Basic Information

Product Name	5-Benzoxazolecarbonyl Chloride, 2,3-Dihydro-3-Methyl-2-Oxo- (9Ci)
CAS No.	154780-55-9
Molecular Formula	C9H6ClNO3
Molecular Weight	211.60 g/mol
Synonyms	3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carbonyl chloride; 5-(Chlorocarbonyl)-3-methyl-2-benzoxazolinone; 3-Methyl-2-benzoxazolinone-5-carbonyl chloride; 2,3-Dihydro-3-methyl-2-oxo-5-benzoxazolecarbonyl chloride; 5-Carboxybenzoxazolone chloride; Benzoxazolone-5-carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Our 5-Benzoxazolecarbonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for pharmaceutical development and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.