Description

3',5'-Dioctanoyl-5-Bromodeuridine is a chemically modified nucleoside analog, specifically a prodrug derivative of 5-bromo-2'-deoxyuridine (BrdU). This compound is engineered to enhance lipophilicity and cellular permeability, making it a crucial intermediate in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for the synthesis of novel therapeutic agents, particularly in oncology and antiviral studies. The product is supplied with a focus on high purity and batch-to-batch consistency to support critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate mechanisms of DNA synthesis and repair.
• Cell Biology Studies: Employed in research involving cell proliferation and tracking, leveraging its bromodeoxyuridine (BrdU) moiety.
• Prodrug Development: Serves as a model compound for designing lipophilic prodrugs to improve the bioavailability of nucleoside analogs.
• Antiviral Agent Synthesis: Intermediate in the development of potential therapeutic agents targeting viral polymerases.
• Oncology Research: Used in the development of chemotherapeutic agents that target rapidly dividing cells.

Basic Information

Item	Details
Product Name	3',5'-Dioctanoyl-5-Bromodeoxyuridine
CAS No.	154653-67-5
Molecular Formula	C25H39BrN2O8
Molecular Weight	575.49 g/mol
Synonyms	5-Bromo-2'-deoxyuridine 3',5'-dioctanoate; BrdU 3',5'-dioctanoyl ester; 1-[(2R,4S,5R)-4-Octanoyloxy-5-(octanoyloxymethyl)oxolan-2-yl]-5-bromopyrimidine-2,4-dione; 3',5'-Di-O-octanoyl-5-bromo-2'-deoxyuridine; 5-BrdU dioctanoate; 5-Bromo-1-[(2R,4S,5R)-4-(octanoyloxy)-5-[[(octanoyloxy)methyl]tetrahydrofuran-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 3',5'-Dioctanoyl-5-Bromodeoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or production requirements. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.