Description

1-[(2R)-4-[5-[(4-Fluorophenyl)Methyl]Thiophen-2-Yl]But-3-Yn-2-Yl]-1-Hydroxy-Urea is a specialized chiral organic compound featuring a unique molecular architecture combining a fluorinated phenyl ring, a thiophene heterocycle, and a hydroxyurea pharmacophore. This compound matters as a high-purity advanced pharmaceutical intermediate critical for research and development in targeted drug discovery programs. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing novel therapeutic agents, particularly in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the development of protein kinase inhibitors for cancer therapy.
• Biochemical Probe Synthesis: Utilized to create labeled or modified probes for studying enzyme function and cellular signaling mechanisms.
• Preclinical Drug Development: Employed in the scale-up synthesis of compounds for pharmacological and toxicological evaluation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical innovation pipelines.

Basic Information

Product Name	1-[(2R)-4-[5-[(4-Fluorophenyl)Methyl]Thiophen-2-Yl]But-3-Yn-2-Yl]-1-Hydroxy-Urea
CAS No.	154355-76-7
Molecular Formula	C₁₆H₁₅FN₂O₂S
Molecular Weight	318.37 g/mol
Synonyms	1-Hydroxy-1-[(2R)-4-[5-[(4-fluorophenyl)methyl]-2-thienyl]-2-butynyl]urea; (R)-1-Hydroxy-1-(4-(5-((4-fluorobenzyl)thiophen-2-yl)but-3-yn-2-yl)urea; UNII-8JQ5607E6I; 8JQ5607E6I; 154355-76-7; (2R)-1-(Hydroxyamino)-4-[5-[(4-fluorophenyl)methyl]-2-thienyl]-2-butyn-1-one oxime; A potential kinase inhibitor intermediate.
EINECS	Contact for details

Quality Control

Our 1-[(2R)-4-[5-[(4-Fluorophenyl)Methyl]Thiophen-2-Yl]But-3-Yn-2-Yl]-1-Hydroxy-Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.