Description

Marimastat is a potent and selective synthetic inhibitor of matrix metalloproteinases (MMPs), a class of enzymes involved in tissue remodeling and degradation. This compound is of significant interest in pharmaceutical research for its potential to modulate pathological processes such as tumor metastasis, angiogenesis, and inflammatory diseases. It serves as a critical research chemical and reference standard for scientists in oncology, cardiology, and neurology. The product is supplied as Marimastat CAS NO 154039-60-8, ensuring precise identification for global research and development applications.

Application

• Pharmaceutical R&D: Used as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutic agents.
• Oncology Research: Investigated for its anti-metastatic and anti-angiogenic properties in various cancer models, including breast, prostate, and colorectal cancers.
• Cardiovascular Disease Studies: Applied in research exploring the role of MMPs in atherosclerosis, aneurysm formation, and heart failure.
• Neurodegenerative Disease Research: Utilized in studies targeting MMP involvement in conditions such as Alzheimer's disease, multiple sclerosis, and stroke.
• Inflammatory & Autoimmune Disorder Models: Employed to study MMP inhibition in arthritis, periodontal disease, and other inflammatory pathologies.
• Biochemical Assay Development: Serves as a precise control and calibration standard in enzymatic activity assays and high-throughput screening (HTS) platforms.

Basic Information

Product Name	Marimastat
CAS No.	154039-60-8
Molecular Formula	C₂₀H₃₀N₄O₆
Molecular Weight	422.48 g/mol
Synonyms	BB-2516; TA-2516; Marimastatum; N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-1,3-butanediamide; (2S)-2-[(Hydroxyamino)carbonyl]-4-methylpentyl-N1-[(1S)-1-(benzylcarbamoyl)-2-(methylamino)-2-oxoethyl]-L-leucinamide; L-N-(Tert-Butoxycarbonyl)leucinyl-L-phenylalanine N-Methylamide Hydroxamate; Matrix Metalloproteinase Inhibitor BB-2516
EINECS	Contact for details

Quality Control

Our Marimastat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant guidelines for research-grade chemicals, and specifications can be tailored to meet specific project requirements. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions, ideally with desiccant. For long-term storage, consider storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.