Description

2H-Pyran-2-Carbonyl Chloride, Tetrahydro-, (R)- (9Ci) is a high-value, enantiomerically pure chiral building block. This compound matters as a critical intermediate for the synthesis of complex pharmaceutical molecules and fine chemicals, where its defined stereochemistry is essential for biological activity. It is primarily needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system (CNS) drug candidates.
• Asymmetric Synthesis: Used as a versatile reagent in stereoselective reactions, including nucleophilic acylations and the construction of complex heterocyclic systems.
• Agrochemical Research: Serves as a precursor in the synthesis of novel, enantiopure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for transition metal catalysis and organocatalysts.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring high optical purity.
• Academic & Contract Research: Essential material for methodological research in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	2H-Pyran-2-Carbonyl Chloride, Tetrahydro-, (R)- (9Ci)
CAS No.	154001-94-2
Molecular Formula	C6H7ClO2
Molecular Weight	146.57 g/mol
Synonyms	(R)-Tetrahydro-2H-pyran-2-carbonyl chloride; (R)-Oxane-2-carbonyl chloride; (R)-2-Tetrahydropyrancarbonyl chloride; (R)-THP-COCl; (R)-Tetrahydro-2-pyranoyl chloride; (R)-2-Chlorocarbonyltetrahydropyran; (R)-Hexahydro-2H-pyran-2-carbonyl chloride; (R)-2-(Chlorocarbonyl)tetrahydropyran
EINECS	Contact for details

Quality Control

Our 2H-Pyran-2-Carbonyl Chloride, Tetrahydro-, (R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and acid chloride nature. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.