Description

Aureobasidin S4 is a potent antifungal compound belonging to the cyclic depsipeptide class, derived from the fungus *Aureobasidium pullulans*. This high-purity standard is critical for research and development in antifungal drug discovery and agricultural chemistry. It serves as an essential reference material for pharmaceutical, biotechnology, and agrochemical industries requiring precise biological activity studies.

Application

• Antifungal Research Standard: Used as a primary reference standard in biochemical and microbiological assays to study fungal cell wall biosynthesis and mode of action.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the discovery and development of novel antifungal therapeutics targeting invasive fungal infections.
• Agricultural Chemistry: Employed in research for developing next-generation fungicides to protect crops from pathogenic fungi.
• Mechanistic Studies: Utilized in academic and industrial laboratories to investigate the inhibition of inositol phosphorylceramide (IPC) synthase, a critical enzyme in fungal sphingolipid synthesis.
• Quality Control: Acts as a certified reference material (CRM) for the quality assurance and potency testing of antifungal products and formulations.
• Biochemical Tool Compound: Provides a selective tool for probing sphingolipid metabolism and signal transduction pathways in eukaryotic cells.

Basic Information

Product Name	Aureobasidin S4
CAS No.	153954-75-7
Molecular Formula	C61H92N8O13
Molecular Weight	1145.4 g/mol
Synonyms	Aureobasidin S4; Aureobasidin S-4; Antibiotic A 192411.2; AbA S4; Cyclic Depsipeptide Antibiotic S4; (3S,6R,7S,10S,11R,14S,19S,22S,26S,30S,31S,34S,38S)-19,22-Diethyl-38-[(1R)-1-hydroxyethyl]-3,7,11,14,26,31-hexamethyl-6-[[(2S)-1-oxo-1-[(2S,3S)-3-phenyl-2-(phenylmethyl)butyl]amino]propan-2-yl]amino]-10-(2-methylpropyl)-2,5,9,12,15,18,21,24,27,30,33,36-dodecaoxo-1-oxa-4,8,13,17,20,23,28,32,35-nonaazacyclooctatriacontane-31-carboxylic acid
EINECS	Contact for details

Quality Control

Our Aureobasidin S4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and biological activity assays. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Potency	Assayed vs. reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.