Description

4-Oxazolecarbonyl Chloride, 2-(1,1-Dimethylethyl)- (9Ci) is a highly reactive acyl chloride derivative of a substituted oxazole, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the sterically hindered 2-(tert-butyl)oxazole-4-carbonyl moiety, a privileged scaffold in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for its role in constructing complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates containing oxazole-based pharmacophores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the tert-butyloxazole unit confers specific biological activity and stability.
• Material Science Research: Employed in the creation of specialized polymers and organic electronic materials that incorporate heterocyclic components for enhanced properties.
• Peptide Mimetics & Bioconjugation: Acts as an acylating agent for modifying peptides or creating stable amide bonds with amines in complex molecular systems.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing novel ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) providers offering bespoke synthetic routes.

Basic Information

Product Name	4-Oxazolecarbonyl Chloride, 2-(1,1-Dimethylethyl)- (9Ci)
CAS No.	153683-97-7
Molecular Formula	C8H10ClNO2
Molecular Weight	187.62 g/mol
Synonyms	2-tert-Butyloxazole-4-carbonyl chloride; 2-(tert-Butyl)-1,3-oxazole-4-carbonyl chloride; 2-(1,1-Dimethylethyl)-4-oxazolecarbonyl chloride; 2-tert-Butyl-4-oxazolecarboxylic acid chloride; 2-(tert-Butyl)oxazole-4-carboxylic acid chloride; 4-Carboxy-2-tert-butyloxazole chloride; 153683-97-7
EINECS	Contact for details

Quality Control

Our 4-Oxazolecarbonyl Chloride, 2-(1,1-Dimethylethyl)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with water and alcohols; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.