Description

2'-o-Methyl-5-Methyl-U Cep CAS NO 153631-20-0 is a high-purity, modified nucleoside derivative essential for advanced oligonucleotide synthesis. This compound is a critical building block for the development of therapeutic nucleic acids, offering enhanced stability and specificity. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense oligonucleotides, siRNA, and other cutting-edge genetic medicines.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite precursor for manufacturing antisense drugs and siRNA therapeutics with improved nuclease resistance.
• Research & Development: Used in academic and industrial labs for studying RNA structure, function, and for developing novel gene silencing applications.
• Diagnostic Probe Development: Incorporated into nucleic acid probes and primers to enhance hybridization stability and specificity for diagnostic assays.
• Bioconjugation & Labeling: Serves as a modified base for introducing functional groups or labels into oligonucleotides for tracking and targeting studies.

Basic Information

Product Name	2'-o-Methyl-5-Methyl-U Cep
CAS No.	153631-20-0
Molecular Formula	C12H17N3O6
Molecular Weight	299.28 g/mol
Synonyms	5-Methyl-2'-O-methyluridine CEP; 1-(2-O-Methyl-β-D-ribofuranosyl)-5-methyluracil 3'-CE Phosphoramidite; 2'-O-Methyl-5-methyluridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 2'-O-Me-5-Me-U CEP; 5-Methyl-2'-O-methyluridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 2'-O-Methyl-5-methyluridine CE Phosphoramidite; 2'-OMe-5-MeU CEP
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl-5-Methyl-U Cep is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and moisture analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store the product in a freezer at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and easily oxidized nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.