Description

Plevitrexed CAS NO 153537-73-6 is a high-purity pharmaceutical intermediate and reference standard, specifically a thymidylate synthase inhibitor. This compound is of critical importance for research and development in the field of oncology, particularly for the study of novel chemotherapeutic agents. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for use in analytical method development, bioactivity studies, and formulation research.

Application

• Pharmaceutical Reference Standard: Used for analytical method validation, quality control, and calibration in HPLC, LC-MS, and other chromatographic systems.
• Oncology Research: Serves as a key biochemical tool for studying thymidylate synthase inhibition, a target for anticancer drug development.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed as a critical intermediate in the synthesis and scale-up of investigational new drugs.
• Preclinical Studies: Utilized in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicology profiles.
• Process Development & Optimization: Aids in the development and refinement of synthetic routes for GMP manufacturing.
• Academic Research: Supports biochemical and pharmacological research in university and institutional laboratories.

Basic Information

Product Name	Plevitrexed
CAS No.	153537-73-6
Molecular Formula	C₂₀H₂₃N₇O₆
Molecular Weight	457.45 g/mol
Synonyms	BGC 9331; ZD 9331; (2S)-2-[[4-[(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid; Tomudex analogue; Thymidylate synthase inhibitor ZD9331; Plevitrexed (ZD9331); AG 337 analogue
EINECS	Contact for details

Quality Control

Our Plevitrexed is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.