Description

5'-o-Dimethoxytrityl-2-Fluoro-6-o-(2-(4-Nitrophenyl)Ethyl)-2'-Deoxyinosine is a sophisticated, high-purity nucleoside derivative engineered for advanced oligonucleotide synthesis. This compound is critical for introducing specific modifications into synthetic DNA and RNA sequences, enabling the development of next-generation therapeutic and diagnostic agents. It is an essential building block for pharmaceutical R&D, particularly in the fields of antisense oligonucleotides, aptamers, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA strands.
• Antisense Drug Development: Used to incorporate fluoro-modified nucleosides into antisense oligonucleotides (ASOs) to enhance stability and binding affinity.
• Aptamer Research: Enables the creation of chemically modified aptamers with improved nuclease resistance and target specificity for diagnostic and therapeutic applications.
• siRNA and miRNA Tools: Serves as a modified monomer in the synthesis of small interfering RNA (siRNA) and microRNA (miRNA) analogs for gene silencing studies.
• Diagnostic Probe Fabrication: Utilized in the manufacture of labeled nucleic acid probes for sensitive detection assays and molecular diagnostics.
• Chemical Biology Research: A valuable tool for studying nucleic acid structure, function, and protein-nucleic acid interactions.

Basic Information

Product Name	5'-o-Dimethoxytrityl-2-Fluoro-6-o-(2-(4-Nitrophenyl)Ethyl)-2'-Deoxyinosine
CAS No.	153527-28-7
Molecular Formula	C34H32FN5O8
Molecular Weight	657.65 g/mol
Synonyms	5'-O-DMT-2'-Fluoro-2'-deoxyinosine 6-O-(2-(4-nitrophenyl)ethyl) derivative; 2'-Fluoro-2'-deoxyinosine, 5'-O-(4,4'-dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-; DMT-F-dI(NPE); 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyinosine 6-O-(2-(4-nitrophenyl)ethyl) ether; NPE-protected 2'-Fluoro-2'-deoxyinosine DMT ether; 2'-F-dI(NPE)-DMT; Modified nucleoside phosphoramidite precursor
EINECS	Contact for details

Quality Control

Every batch of 5'-o-Dimethoxytrityl-2-Fluoro-6-o-(2-(4-Nitrophenyl)Ethyl)-2'-Deoxyinosine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural integrity suitable for sensitive pharmaceutical R&D applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.