Description

4'--C-Methylcytidine is a chemically modified nucleoside analog of cytidine, where a methyl group is introduced at the 4'-carbon position of the ribose sugar. This structural modification is of significant interest in medicinal chemistry and biochemistry for its potential to alter biological activity and metabolic stability. It serves as a critical building block and research tool for pharmaceutical companies and academic institutions engaged in the development of novel antiviral agents, anticancer therapeutics, and molecular probes. The compound, identified by CAS No. 153186-29-9, is essential for researchers focusing on nucleoside chemistry and RNA-targeted drug discovery.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a modified nucleoside substrate to study RNA structure, function, and enzyme kinetics.
• Antiviral Drug Discovery: Serves as a core scaffold for developing inhibitors targeting viral polymerases (e.g., HCV, SARS-CoV-2).
• Proteomics & Genomics: Employed in the synthesis of labeled probes for diagnostic assays and next-generation sequencing technologies.
• Academic Research: Fundamental tool for investigating nucleoside metabolism, cellular signaling pathways, and epigenetic modifications.
• Contract Manufacturing (CMO): Supplied as a high-purity raw material for custom synthesis and scale-up processes under cGMP conditions.

Basic Information

Item	Details
Product Name	4'--C-Methylcytidine
CAS No.	153186-29-9
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	4'-C-Methylcytidine; 4'-Methylcytidine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-4-(hydroxymethyl)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 4'-Methyl-Cytidine; Cytidine, 4'-C-methyl-; 4'-C-Methylcytidine (CAS 153186-29-9); 4'-C-Methylcytidine nucleoside
EINECS	Contact for details

Quality Control

Our 4'--C-Methylcytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. For advanced applications, we offer material produced under quality guidelines suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.