Description

5'-(n-Methylcarboxamido)-N(6)-Benzyladenosine is a synthetic nucleoside derivative and a potent, selective agonist for the adenosine A3 receptor (A3AR). This compound is a critical research-grade chemical for investigating adenosine receptor signaling pathways and their physiological roles. It is primarily utilized by pharmaceutical researchers and life science companies engaged in drug discovery, particularly for developing novel therapeutics targeting inflammation, cardiac ischemia, and cancer.

Application

• Pharmacological Research: A key tool compound for studying adenosine A3 receptor (A3AR) activation, signaling, and downstream effects in cellular and in vivo models.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the design of new A3AR-targeting drugs for conditions like inflammatory diseases, glaucoma, and ischemic injury.
• Biochemical Assays: Used in high-throughput screening (HTS) and competitive binding assays to identify and characterize new A3AR ligands or antagonists.
• Signal Transduction Studies: Employed to elucidate the role of A3AR in modulating cAMP levels, MAPK pathways, and other intracellular signaling cascades.
• Academic Research: Essential for university and institutional labs focusing on neuropharmacology, cardioprotection, and immunomodulation.
• Reference Standard: Used for quality control, method development, and calibration in analytical laboratories (HPLC, LC-MS) for related compound analysis.

Basic Information

Product Name	5'-(n-Methylcarboxamido)-N(6)-Benzyladenosine
CAS No.	152918-15-5
Molecular Formula	C20H24N6O5
Molecular Weight	428.44 g/mol
Synonyms	MRS 5698; N6-Benzyl-5'-N-methylcarboxamidoadenosine; 5'-(N-Methylcarboxamido)-N6-benzyladenosine; 2-Chloro-N6-cyclopentyladenosine (Note: This is a common related compound, verify for this specific structure); A3 Adenosine Receptor Agonist; IB-MECA (Isomer); N6-Benzyladenosine-5'-N-methyluronamide; Bn-Ado-5'-N-methylcarboxamide
EINECS	Contact for details

Quality Control

Our 5'-(n-Methylcarboxamido)-N(6)-Benzyladenosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards and can support development under cGMP guidelines for advanced preclinical and clinical-stage projects upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.