Description

Ebrotidine S,S-Dioxide is a key pharmaceutical intermediate and a derivative of the H₂-receptor antagonist ebrotidine. This compound is of significant value in the research and development of novel therapeutic agents, particularly for gastrointestinal applications. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in drug discovery and process chemistry.

Application

• Critical intermediate in the synthesis of ebrotidine and related analogs.
• Research and development of gastrointestinal therapeutics and ulcer treatments.
• Building block for pharmacological studies targeting histamine H₂-receptors.
• Process development and scale-up synthesis in active pharmaceutical ingredient (API) manufacturing.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Starting material for the preparation of sulfone-containing drug candidates in medicinal chemistry.

Basic Information

Product Name	Ebrotidine S,S-Dioxide
CAS No.	152675-29-1
Molecular Formula	C19H20N4O4S2
Molecular Weight	432.52 g/mol
Synonyms	N-[(E)-[[2-[[(2-[(Aminosulfonyl)amino]-4-thiazolyl)methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfonamide S,S-dioxide; Ebrotidine Disulfone; Famosan S,S-Dioxide; 4-Bromo-N-[(E)-[[2-[[[2-[(aminosulfonyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]benzenesulfonamide S,S-dioxide
EINECS	Contact for details

Quality Control

Our Ebrotidine S,S-Dioxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and other relevant pharmacopeial methods to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.