Description

2'-Deoxy-4'-Methyl-4'-Thiothymidine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, particularly in the exploration of modified oligonucleotides and prodrugs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and therapeutic innovation.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in studies targeting viruses such as HIV, hepatitis, and herpes, exploring mechanisms of viral inhibition.
• Anticancer Agent Development: Investigated as a precursor for prodrugs designed to selectively target and disrupt cancer cell DNA replication.
• Oligonucleotide Synthesis: Serves as a modified building block for creating antisense oligonucleotides and siRNA with enhanced stability or targeting properties.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Medicinal Chemistry: A valuable tool for structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic profiles of nucleoside-based drugs.

Basic Information

Product Name	2'-Deoxy-4'-Methyl-4'-Thiothymidine
CAS No.	152594-60-0
Molecular Formula	C11H16N2O4S
Molecular Weight	272.32 g/mol
Synonyms	4'-Thiothymidine, 4'-Methyl-4'-thio derivative; 1-[(2R,4S,5R)-4-Methyl-4-thio-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Deoxy-4'-thio-4'-methylthymidine; 4'-Methyl-4'-thio-2'-deoxythymidine; 4'-S-Methyl-4'-thiothymidine; d4SMeT
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-4'-Methyl-4'-Thiothymidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.